:root{color-scheme:light;--ink:#20262d;--muted:#5b6470;--line:#dce1e6;--surface:#fff;--ground:#f6f7f9;--tint:#edf3fc;--blue:#165ab8;--hover:#e5edfa;--caution:#805000;--caution-bg:#fff5df;--danger:#a22c29;--danger-bg:#fff0ee;--radius:12px;--focus:0 0 0 3px #98bdf0;--font:-apple-system,BlinkMacSystemFont,"Segoe UI",sans-serif}
*{box-sizing:border-box}html{scroll-behavior:smooth;scroll-padding-top:90px}body{margin:0;background:var(--ground);color:var(--ink);font:15px/1.5 var(--font);-webkit-font-smoothing:antialiased}button,select,input{font:inherit;color:inherit}button,select,summary,a,input{touch-action:manipulation}button,a,summary,select{ -webkit-tap-highlight-color:transparent}button{cursor:pointer}button:disabled{cursor:default;opacity:.6}a{color:var(--blue);text-underline-offset:3px}button:focus-visible,a:focus-visible,summary:focus-visible,select:focus-visible,input:focus-visible{outline:2px solid var(--blue);outline-offset:3px}::selection{background:#cddff8;color:#173756}input{caret-color:var(--blue)}h1,h2,h3,p{margin:0}h1{font-size:28px;font-weight:650;letter-spacing:-.025em;line-height:1.2;text-wrap:balance}h2{font-size:19px;font-weight:650;letter-spacing:-.015em;line-height:1.35}h3{font-size:15px;font-weight:650}p{max-width:74ch}svg{display:block;flex:none}button svg,a svg{width:18px;height:18px}small,.small{font-size:12px;line-height:1.5}.muted{color:var(--muted)}.sr-only{position:absolute;width:1px;height:1px;padding:0;overflow:hidden;clip:rect(0,0,0,0);white-space:nowrap;border:0}.skip{position:fixed;top:-100px;left:16px;z-index:10;background:white;padding:12px}.skip:focus{top:12px}.topbar{background:var(--surface);border-bottom:1px solid var(--line)}.top-inner{max-width:1060px;margin:auto;min-height:76px;display:flex;align-items:center;justify-content:space-between;gap:20px;padding:16px 28px}.identity{display:flex;align-items:center;gap:12px}.identity-mark{width:34px;height:34px;display:grid;place-items:center;background:var(--tint);color:var(--blue);border-radius:9px}.identity-mark svg{width:22px;height:22px}.identity strong{font-size:17px;letter-spacing:-.015em;font-weight:650}.identity span{display:block;font-size:12px;color:var(--muted)}.header-actions{display:flex;align-items:center;gap:20px}.text-action{display:inline-flex;align-items:center;gap:7px;color:var(--blue);font-size:13px;font-weight:550;text-decoration:none}.text-action:hover{text-decoration:underline}.review-badge{font-size:11px;padding:3px 8px;border:1px solid var(--line);border-radius:5px;color:var(--muted);white-space:nowrap}.layout{max-width:1060px;margin:0 auto;display:grid;grid-template-columns:236px minmax(0,1fr);gap:40px;padding:32px 28px 0}.sidebar{min-width:0}.mobile-product-picker{display:none}.rail-title{font-size:13px;font-weight:650;margin-bottom:12px}.product-list{display:grid;gap:5px}.product-choice{width:100%;text-align:left;padding:12px 13px;border:1px solid transparent;background:transparent;border-radius:10px;display:flex;align-items:center;gap:10px;min-height:70px}.product-choice:hover{background:#eef0f3}.product-choice[aria-pressed=true]{background:var(--tint);border-color:#b8cee9;color:#124a94}.product-choice .choice-text{flex:1;min-width:0}.choice-text strong{display:block;font-size:14px;font-weight:600}.choice-text span{display:block;font-size:12px;margin-top:3px;color:var(--muted)}.product-choice[aria-pressed=true] .choice-text span{color:#3c5879}.check{width:16px;height:16px;color:var(--blue);visibility:hidden}.product-choice[aria-pressed=true] .check{visibility:visible}.more-products{margin-top:20px;padding-top:20px;border-top:1px solid var(--line)}label.select-label{display:block;font-size:12px;font-weight:550;margin-bottom:8px}select{border:1px solid #bcc5cf;background:white;border-radius:8px;min-height:42px;padding:8px 30px 8px 10px;width:100%;font-size:12px}.rail-note{margin-top:24px;font-size:12px;color:var(--muted);line-height:1.6}.rail-link{display:inline-flex;align-items:center;gap:5px;font-size:12px;margin-top:18px;text-decoration:none}.rail-link:hover{text-decoration:underline}.main{min-width:0;padding-bottom:30px}.product-heading{padding:0 0 20px}.product-heading .subline{font-size:13px;color:var(--muted);margin-top:8px}.subline .dot{padding:0 6px;color:#9098a3}.label-dose{background:var(--surface);border:1px solid var(--line);border-radius:var(--radius);padding:16px 18px;margin-bottom:26px}.dose-title{font-size:12px;font-weight:650;color:var(--muted);margin-bottom:5px}.dose-copy{font-size:14px;line-height:1.6}.citation{display:inline;color:var(--blue);font-size:11px;line-height:1.5;text-decoration:none;border-bottom:1px dotted #a0badd;white-space:normal;margin-left:4px}.citation:hover{border-color:var(--blue);background:var(--tint)}.citation:focus-visible{outline-offset:2px}.section-heading{display:flex;gap:12px;align-items:center;justify-content:space-between;margin-bottom:13px}.section-heading .quiet-action{border:0;background:none;padding:7px 0;color:var(--blue);font-size:12px;display:flex;align-items:center;gap:5px}.quiet-action:hover{text-decoration:underline}.scenarios{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:10px;margin-bottom:24px}.scenarios.single{grid-template-columns:1fr}.scenario{position:relative;border:1px solid var(--line);border-radius:10px;background:white;padding:12px 14px}.scenario:has(input:checked){border-color:#8eb4e5;background:var(--tint)}.scenario label{cursor:pointer;display:flex;gap:9px;align-items:flex-start}.scenario input{accent-color:var(--blue);width:16px;height:16px;margin:3px 0 0;flex:none}.scenario strong{font-weight:600;font-size:13px}.scenario .scenario-dose{display:block;font-size:12px;color:var(--muted);margin-top:3px}.scenario .citation{display:inline-block;margin:5px 0 0 25px;font-size:10px}.scope-line{color:var(--muted);font-size:12px;display:flex;align-items:center;flex-wrap:wrap;gap:7px;margin-top:-8px;margin-bottom:17px}.scope-line span+span:before{content:'·';margin-right:7px}.panel{background:var(--surface);border:1px solid var(--line);border-radius:var(--radius);overflow:hidden}.panel-top{padding:20px 22px 17px}.comparator-line{font-size:13px;line-height:1.65;margin-top:10px}.comparator-line .formulation{display:block;font-size:11px;color:var(--muted);margin-top:2px}.study-facts{display:grid;grid-template-columns:1fr 1fr;gap:22px;margin-top:17px}.study-facts dt{font-size:11px;color:var(--muted);margin-bottom:4px;font-weight:550}.study-facts dd{margin:0;font-size:13px;line-height:1.6}.study-facts .formulation{color:var(--muted);display:block;font-size:12px;margin-top:3px}.source-note{font-size:12px;line-height:1.55;color:var(--caution);background:var(--caution-bg);padding:11px 14px;margin-top:14px;border-radius:7px}.table-wrap{padding:0 22px}.pk-table{width:100%;border-collapse:collapse;table-layout:fixed;font-variant-numeric:tabular-nums}.pk-table th{font-size:11px;font-weight:600;color:var(--muted);text-align:left;border-bottom:1px solid var(--line);padding:0 0 10px}.pk-table th:first-child{width:30%}.pk-table th:not(:first-child){padding-left:15px}.pk-table td{vertical-align:top;padding:15px 0;border-bottom:1px solid #edf0f3}.pk-table td:not(:first-child){padding-left:15px}.pk-table tr:last-child td{border-bottom:none}.metric-name{font-weight:600;font-size:13px}.metric-unit{font-size:11px;color:var(--muted);display:block;margin-top:3px}.metric-source{display:block;margin-top:7px;line-height:1.2}.metric-source .citation{margin-left:0;font-size:10px}.measure{font-size:20px;font-weight:600;letter-spacing:-.02em;white-space:nowrap;line-height:1.25}.variability{font-size:11px;color:var(--muted);display:block;margin-top:5px;line-height:1.5}.unknown-value{font-size:12px;color:var(--muted);display:block;padding-top:3px}.mini-bar{height:3px;max-width:100%;background:var(--blue);margin-top:9px;border-radius:2px;min-width:1px}.mini-bar.oral{background:#6f7f90}.table-caption{font-size:11px;color:var(--muted);padding:0 22px 14px}.reported-comparison{margin:0 22px 18px;padding:13px 0 0;border-top:1px solid var(--line)}.reported-comparison h3{font-size:12px;margin-bottom:5px}.reported-comparison p{font-size:13px;line-height:1.6}.reported-comparison .percentage{font-size:16px;font-weight:650}.reported-comparison .denominator{font-size:11px;color:var(--muted);margin-top:4px}.expandable{border-top:1px solid var(--line);padding:0 22px}.expandable summary{font-size:12px;font-weight:550;cursor:pointer;padding:14px 0;color:var(--blue)}.expandable[open] summary{padding-bottom:10px}.expand-content{padding-bottom:18px;font-size:12px;line-height:1.6}.expand-content p+p{margin-top:10px}.detail-grid{display:grid;grid-template-columns:1fr 1fr;gap:14px 25px;margin:0 0 18px}.detail-grid dt{font-size:11px;color:var(--muted);margin-bottom:3px}.detail-grid dd{margin:0}.limits{margin:12px 0 0;padding-left:18px}.limits li+li{margin-top:6px}.renal-section{margin-top:28px}.renal-head{display:flex;align-items:center;gap:8px;margin-bottom:13px}.renal-head svg{width:18px;height:18px;color:var(--muted)}.tabs{display:flex;gap:4px;border-bottom:1px solid var(--line);margin-bottom:16px}.tab{background:none;border:0;border-bottom:2px solid transparent;padding:9px 13px 10px;color:var(--muted);font-size:12px;font-weight:550;min-height:42px}.tab[aria-selected=true]{color:var(--blue);border-bottom-color:var(--blue)}.tab:hover{background:#edf0f4}.renal-copy{font-size:13px;line-height:1.65}.renal-copy p+p{margin-top:10px}.renal-copy .classification{font-weight:600}.renal-copy .contra{color:var(--danger)}.renal-copy .muted{font-size:12px}.renal-copy details{margin-top:12px}.renal-copy summary{color:var(--blue);font-size:12px;cursor:pointer}.renal-copy details p{margin-top:10px}.outcome-row{display:grid;grid-template-columns:minmax(0,1fr) auto;gap:18px;padding:11px 0;border-bottom:1px solid var(--line)}.outcome-row strong{font-size:14px;font-variant-numeric:tabular-nums}.outcome-row .small{color:var(--muted);display:block}.formulation-section{margin-top:26px;border-top:1px solid var(--line);padding-top:4px}.formulation-section>summary{font-size:13px;font-weight:550;cursor:pointer;padding:14px 0;color:var(--blue)}.formulation-body{font-size:12px;line-height:1.65;padding-bottom:10px}.formulation-body p+p{margin-top:10px}.notice-empty{padding:26px 22px}.notice-empty svg{color:var(--muted);width:26px;height:26px;margin-bottom:15px}.notice-empty h2{font-size:19px;margin-bottom:9px}.notice-empty p{font-size:13px;color:var(--muted);line-height:1.65}.empty-link{display:inline-flex;margin-top:15px;font-size:12px}.site-options{display:flex;flex-wrap:wrap;gap:7px;margin-bottom:16px}.site-button{padding:8px 12px;border:1px solid var(--line);background:white;border-radius:8px;font-size:12px;min-height:40px}.site-button[aria-pressed=true]{color:var(--blue);border-color:#8eb4e5;background:var(--tint)}.site-button:hover{background:var(--hover)}.custom-fields{display:flex;align-items:end;gap:12px;margin:0 0 20px}.custom-fields label{display:block;font-size:12px;color:var(--muted);margin-bottom:7px}.custom-fields input{width:150px;border:1px solid #bcc5cf;background:#fff;min-height:40px;border-radius:8px;padding:8px 10px}.custom-fields input[type=text]{width:200px}.custom-fields .unit{font-size:12px;margin-left:6px}.custom-caption{font-size:11px;color:var(--muted);margin-top:6px}.ingredients{margin:18px 0 0;display:grid;grid-template-columns:1fr 1fr;gap:7px 25px}.ingredients div{display:flex;justify-content:space-between;gap:12px;border-bottom:1px solid var(--line);padding:6px 0;font-size:13px}.ingredients dt,.ingredients dd{margin:0}.ingredients dd{font-variant-numeric:tabular-nums;font-weight:600}.site-context{font-size:12px;color:var(--muted);margin:12px 0 18px}.footer{max-width:1060px;padding:0 28px 32px;margin:12px auto 0}.footer-inner{border-top:1px solid var(--line);padding-top:18px}.footer-row{display:flex;justify-content:space-between;gap:18px;align-items:center;font-size:11px;color:var(--muted)}.footer-actions{display:flex;gap:18px;flex-wrap:wrap}.footer-actions a{font-size:12px;text-decoration:none}.footer-actions a:hover{text-decoration:underline}.footer-note{font-size:11px;color:var(--muted);margin-top:12px}.references{margin-top:18px}.references>summary{font-size:13px;color:var(--blue);font-weight:550;cursor:pointer;padding:8px 0}.ref-toolbar{display:flex;align-items:center;gap:18px;justify-content:space-between;margin:16px 0}.ref-toolbar input{border:1px solid #bcc5cf;background:#fff;border-radius:8px;padding:10px 12px;font-size:12px;width:320px;max-width:100%;min-height:42px}.ref-list{margin:0;padding:0;list-style:none;display:grid;gap:0}.ref-item{padding:17px 16px 17px 36px;border-top:1px solid var(--line);font-size:12px;line-height:1.65;scroll-margin-top:30px;overflow-wrap:anywhere}.ref-item:target,.ref-item.is-highlighted{background:var(--tint);border-radius:8px}.apa{padding-left:20px;text-indent:-20px;max-width:95ch}.ref-meta{font-size:11px;color:var(--muted);margin-top:8px;max-width:90ch}.ref-locator{font-size:11px;color:#254e80;font-weight:600;margin-top:7px}.ref-empty{font-size:13px;padding:20px;color:var(--muted)}.preview-note{display:none}.noscript{padding:35px;max-width:650px;margin:auto}.surface-update{animation:surface-in 180ms ease-out}@keyframes surface-in{from{background-color:#f0f5fd}to{background-color:transparent}}@media(prefers-reduced-motion:reduce){html{scroll-behavior:auto}.surface-update{animation:none}}@media(min-width:1000px){.sidebar{align-self:start;position:sticky;top:28px}}@media(max-width:1000px){.layout{gap:25px;grid-template-columns:210px minmax(0,1fr);padding:26px 22px 0}.top-inner{padding-inline:22px}.product-choice{padding:10px}.measure{font-size:18px}}@media(max-width:760px){.top-inner{padding:14px 20px;min-height:70px}.header-actions{gap:14px}.header-actions .evidence-link{display:none}.review-badge{display:none}.layout{display:block;padding:22px 20px 0}.sidebar{margin-bottom:25px}.rail-title{margin-bottom:9px}.mobile-product-picker{display:block;font-size:13px;min-height:43px}.product-list{display:none}.product-choice{min-height:66px;background:#fff;border-color:var(--line)}.choice-text strong{font-size:12px}.choice-text span{font-size:11px}.check{width:13px;height:13px}.more-products{display:none}.more-products label{margin:0;flex:none;font-size:11px}.more-products select{min-height:36px;font-size:11px}.rail-note,.rail-link{display:none}h1{font-size:24px}.product-heading{padding-bottom:15px}.label-dose{margin-bottom:22px;padding:13px 15px}.dose-copy{font-size:12px}.section-heading h2{font-size:17px}.section-heading{margin-bottom:11px}.section-heading .quiet-action{font-size:11px}.scenarios{gap:8px;margin-bottom:22px}.scenario{padding:10px}.scenario strong{font-size:12px}.scenario .scenario-dose{font-size:11px}.scenario .citation{font-size:9px}.panel-top{padding:18px 16px 15px}.panel-top h2{font-size:17px}.study-facts{gap:15px;margin-top:14px}.study-facts dd{font-size:12px}.study-facts .formulation{font-size:11px}.table-wrap{padding:0 16px}.pk-table th:first-child{width:31%}.pk-table th:not(:first-child),.pk-table td:not(:first-child){padding-left:10px}.pk-table td{padding:14px 0}.measure{font-size:18px}.metric-name{font-size:12px}.metric-unit{font-size:10px}.metric-source .citation{font-size:9px}.variability{font-size:10px}.table-caption{padding:0 16px 12px;font-size:10px}.reported-comparison{margin:0 16px 15px}.reported-comparison p{font-size:12px}.reported-comparison .denominator{font-size:10px}.expandable{padding:0 16px}.renal-section{margin-top:25px}.renal-copy{font-size:12px}.tab{padding:9px 12px;font-size:11px}.footer{padding:0 20px 25px;margin-top:0}.footer-row{align-items:flex-start;flex-direction:column;gap:11px}.footer-note{font-size:10px}.ref-toolbar{align-items:flex-start;flex-direction:column;gap:10px}.ref-toolbar input{width:100%}.ref-item{padding:15px 6px 15px 16px;font-size:11px}.ref-meta,.ref-locator{font-size:10px}.notice-empty{padding:22px 17px}.notice-empty p{font-size:12px}.detail-grid{grid-template-columns:1fr}.custom-fields{flex-wrap:wrap}.scope-line{font-size:11px}.source-note{font-size:11px}}
@media(max-width:360px){.layout{padding-inline:14px}.top-inner{padding-inline:14px}.identity strong{font-size:15px}.identity-mark{display:none}.header-actions .text-action{font-size:11px}.scenarios{grid-template-columns:1fr}.measure{font-size:16px}.footer{padding-inline:14px}}
@media print{.sidebar,.header-actions,.scenarios,.section-heading .quiet-action,.site-options,.custom-fields,.footer-actions,.ref-toolbar,.tabs{display:none!important}.layout{display:block;padding:15px 0}.topbar{border:0}.top-inner{padding:0}.main{padding:0}body{background:#fff;font-size:11px}.panel{break-inside:avoid}.footer{padding:0}.ref-list{display:block}.citation{color:#222}.references:not([open]){display:none}}

#app-root{display:flow-root}#app-identity[hidden]{display:none}#app-identity a{text-decoration:none}#app-identity a:hover{text-decoration:underline}

/* Evidence detail uses the same two primary destinations as the product guide. */
.identity{text-decoration:none;color:var(--ink)}.header-actions .text-action{padding:8px 0;border-bottom:2px solid transparent;min-height:42px}.header-actions .text-action[aria-current]{border-color:var(--blue);font-weight:650}.evidence-breadcrumb{max-width:1060px;margin:0 auto;padding:22px 28px 0;display:flex;flex-wrap:wrap;align-items:center;gap:10px;font-size:12px;color:var(--muted)}.evidence-breadcrumb #product-return{margin-left:auto}.layout{padding-top:24px}.review-badge{display:none}
@media(max-width:760px){.top-inner{flex-wrap:wrap;gap:12px}.header-actions{gap:24px}.evidence-breadcrumb{padding:18px 20px 0}.header-actions .text-action{font-size:13px}}

.study-population{margin-top:8px}.composition-note{margin-top:12px}.renal-limit{margin-top:10px}