/* Shared NephRxTools chrome, isolated from each reference's reading styles. */
.nephrx-shell{--ink:#193b39;--muted:#526765;--teal:#17675d;--line:#cfdbd4;max-width:none;width:100%;margin:0;padding:0;color:var(--ink);font:16px/1.6 -apple-system,BlinkMacSystemFont,"Segoe UI",sans-serif;letter-spacing:normal}
.nephrx-shell a{color:inherit;text-underline-offset:.22em}
.nephrx-shell a:focus-visible{outline:3px solid var(--teal);outline-offset:4px}
.nephrx-shell .header-inner,.nephrx-shell .footer-main,.nephrx-shell .footer-bottom{width:min(1184px,calc(100% - 96px));margin-inline:auto}
.nephrx-shell.site-header{background:#f7f8f4;border-bottom:1px solid var(--line)}
.nephrx-shell .header-inner{display:flex;align-items:center;justify-content:space-between;gap:24px;min-height:72px}
.nephrx-shell .brand{display:inline-flex;align-items:center;text-decoration:none}
.nephrx-shell .brand-name{display:inline;font-size:26px;font-weight:650;line-height:1.6;letter-spacing:-1.1px;white-space:nowrap;color:var(--ink)}
.nephrx-shell .brand-name>span:first-child{display:inline;font-size:inherit;font-weight:inherit;color:var(--teal)}
.nephrx-shell .brand-dot{display:inline;font-size:32px;font-weight:650;color:var(--teal)}
.nephrx-shell .header-inner nav{display:flex;gap:32px;align-items:center}
.nephrx-shell .header-inner nav a{font-size:14px;font-weight:400;text-decoration:none;padding:12px 4px;min-width:44px;min-height:44px;text-align:center;position:relative;border:0}
.nephrx-shell .header-inner nav a:hover,.nephrx-shell .header-inner nav a[aria-current]{color:var(--teal)}
.nephrx-shell .header-inner nav a[aria-current]:after{content:"";position:absolute;bottom:5px;left:0;right:0;height:2px;background:var(--teal)}
.nephrx-shell.site-footer{border-top:1px solid var(--line);background:#edf1eb}
.nephrx-shell .footer-main{display:flex;align-items:center;justify-content:space-between;gap:24px;padding-block:16px 8px;font-size:13px;color:var(--muted)}
.nephrx-shell .footer-links{display:flex;flex-direction:row;flex-wrap:wrap;gap:24px;border:0;padding:0;margin:0}
.nephrx-shell .footer-links a{display:inline-flex;align-items:center;min-height:44px;text-decoration:none;border:0;font-size:13px;padding:0}
.nephrx-shell .footer-bottom{display:flex;justify-content:space-between;gap:20px;padding-block:12px 18px;font-size:12px;color:var(--muted)}
.nephrx-shell .footer-bottom a{text-decoration:none}
.nephrx-shell .footer-links a:hover,.nephrx-shell .footer-bottom a:hover{text-decoration:underline}
.reference-page>.skip-link{position:fixed;top:8px;left:16px;z-index:20;padding:12px 20px;background:white;transform:translateY(-180%);color:#17675d}
.reference-page>.skip-link:focus{transform:none}
.publication-status{font-size:13px;color:var(--muted);margin:0}
.publication-status b{font-weight:600;color:var(--ink)}
.reference-page .top,.reference-page .top-inner{padding-block:10px;min-height:64px}
@media(max-width:900px){.nephrx-shell .header-inner,.nephrx-shell .footer-main,.nephrx-shell .footer-bottom{width:calc(100% - 48px)}}
@media(max-width:640px){
 .nephrx-shell .header-inner,.nephrx-shell .footer-main,.nephrx-shell .footer-bottom{width:calc(100% - 40px)}
 .nephrx-shell .header-inner{gap:8px 20px;flex-wrap:wrap;padding-block:8px}
 .nephrx-shell .brand-name{font-size:23px}.nephrx-shell .brand-dot{font-size:28px}
 .nephrx-shell .header-inner nav{gap:12px}
 .nephrx-shell .footer-main{display:block;padding-top:20px}
 .nephrx-shell .footer-links{margin-top:4px}
 .nephrx-shell .footer-bottom{flex-wrap:wrap;gap:10px}
 .reference-page .top,.reference-page .top-inner{flex-wrap:wrap;gap:4px 20px}
 .publication-status{font-size:12px}
}
@media print{.nephrx-shell,.reference-page>.skip-link{display:none}}